The breakdown and elimination of tadalafil from the body may be decreased by erythromycin, ketoconazole (nizoral), itraconazole (sporanox), indinavir (crixivan) and ritonavir (norvir).
therefore, these drugs may increase the concentration of tadalafil in the blood. if these drugs are being used at the same time as tadalafil, the dose of tadalafil should be reduced in order to avoid side effects from high levels of tadalafil.
tadalafil increases the heart rate and also exaggerates the blood pressure
| Read More on Possible food and drug interactions when taking tadalafil