Drug Class: What is Singulair and why is it prescribed?
Singulair Mechanism: How does Singulair work?
Singulair Dosage: How should you take Singulair?
Possible food and drug interactions when taking Singulair
Special information on Singulair
Singulair side effects
|Drug Class: What is Singulair and why is it prescribed?|
|Generic Singulair, (Montelukast) is an oral leukotriene receptor antagonist for the treatment of asthma and seasonal allergic rhinitis (hay fever). Generic Singulair reduces the swelling and inflammation that tend to close up the airways, and relaxes the walls of the bronchial tubes, expanding the airways and permitting more air to pass through.|
|Singulair Mechanism: How does Singulair work?|
Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important (such as allergy). They are formed by cells, released, and then bound to other cells, and it is the binding to these other cells that stimulates the cells to promote inflammation.
Generic Singulair (Montelukast) works in a manner similar to zafirlukast (Accolate), blocking the binding of some leukotrienes. Unlike zafirlukast, Generic Singulair (montelukast) does not inhibit CYP2C9 or CYP3A4, two enzymes in the liver that are important in breaking down and eliminating many drugs. Therefore, unlike zafirlukast, Generic Singulair (montelukast) is not expected to affect the elimination of other drugs.
The safety and effectiveness of Generic Singulair has been demonstrated in children as young as 6 years of age. Generic Singulair was approved by the FDA in 1998.
|Singulair Dosage: How should you take Singulair?|
|Take a Generic Singulair tablet regularly every evening, whether or not you have
any symptoms. The Generic Singulair tablet can be taken with or without food.
If you miss a Generic Singulair dose: Take it as soon as you remember. If it is almost time for your next Generic Singulair dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses of Generic Singulair at once.
Storage information for Generic Singulair: Store Generic Singulair at room temperature, away from moisture and light.
|Possible food and drug interactions when taking Singulair|
If Generic Singulair is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Generic Singulair with the following:
|Special information on Singulair|
|Generic Singulair should be used during pregnancy only if clearly needed. If you
are pregnant or plan to become pregnant, inform your doctor immediately. It is
not known whether Generic Singulair appears in breast milk. Because many drugs
do make their way into breast milk, use Generic Singulair with caution if you are
After you begin taking Generic Singulair, your doctor may be able to slowly reduce the dosage of other asthma medications such as inhaled steroids. However, Generic Singulair is not a complete replacement for such drugs, so you should not abruptly stop using them unless your doctor recommends it. If your asthma symptoms get worse or you develop a rash, numbness, or heart problems as you reduce your dose of steroids, check with your doctor. Such reactions usually result from a reduction in oral steroid therapy. If your asthma gets worse after exercise, you will need to continue using a short-acting inhaled airway opener to prevent the problem and relieve attacks. If you are allergic to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), you should continue to avoid them. Generic Singulair does not remedy this problem.
If you have difficulty breathing while taking Generic Singulair, or find that you need your orally inhaled bronchodilator more often than usual (or require more puffs than prescribed), notify your doctor. If you have a child with phenylketonuria--an inability to process phenylalanine that quickly leads to mental retardation--you should be aware that Generic Singulair chewable tablets contains this substance.
|Singulair side effects|
|The most common side effects of Generic Singulair with montelukast are headache, dizziness, abdominal pain, sore throat, and rhinitis (inflammation of the inner lining of the nose). These side effects of Generic Singulair occur in 1 in 50 to 1 in 7 persons who take montelukast.|
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