About Clomiphene (Clomifene) Citrate
Category: Fertility Agent
Contents: Clomiphene (Clomifene) Citrate
Clomiphene (Clomifene) Citrate Prices
|Drug Class: What is Clomid & and why is it prescribed?
|Clomid, Clomiphene is prescribed for the treatment of ovulatory failure in women who wish to become pregnant and whose husbands are fertile and potent.
|Clomid Mechanism: How does Clomid work?
| Clomid (Clomiphene) is the most commonly used drug
in cases where lack of ovulation in the female body is preventing pregnancy. Ovulation,
which is essential for the regular menstrual cycle and for pregnancy, is preceded
by a chain of events involving several hormones and beginning during the prior
Clomid works by influencing the interaction of these four hormones: GnRH (gonotropin
releasing hormone), FSH (follicle stimulating hormone), LH (luteinizing hormone),
Estradiol. Toward the end of a normal cycle, the body levels of estrogen and
progesterone slowly decrease. During the first days of the next menstrual cycle,
the lower levels of those two hormones eventually trigger production of GnRH in
the hypothalamus. GnRH then stimulates the pituitary gland to produce FSH and
LH, also called gonatropins, which directly affect ovulation: FSH is responsible
for the growth of both follicles and eggs and for increasing the size and number
of the follicles.
The level of LH suddenly increases one to two days before ovulation, which causes
the eggs to be released. Estradiol is a hormone produced by the ovaries and the
corpus luteum, or tissue left behind in the ovary after ovulation. Among other
things, estradiol aids in the development of the uterine lining and the eggs.
If GnRH, LH, or FSH are not produced in the right amount and at the right time,
the ovaries will not release eggs.
In some medical conditions such as polycystic ovary syndrome, the body produces
too much estrogen, which may interfere with the production of GnRH, LH, and FSH
and cause anovulation. Although a lot about how Clomid works is still not
known, we do know that it tricks the body into believing that the body estrogen
level is low. The body then produces more GnRH, causing the pituitary to pump
out more of FSH and LH eventually triggering the release of an egg from the ovary.
Clomid a very powerful drug and induces ovulation in more than 50% of women
who take it. Clomid is usually taken in pill form once a day for five days.
Clomid (Clomiphene citrate) was approved by the FDA in the U.S. in 1967.
|Clomid Dosage: How should you take Clomid?
|One should take Clomid exactly as prescribed by doctor. The recommended
dosage of Clomid for the first course of treatment is 50 milligrams (1
tablet) daily for 5 days. If ovulation does not appear to have occurred, your
doctor may try up to 2 more times.
Clomid Overdose: Taking any medication in excess can have serious consequences.
If you suspect an overdose of clomiphene, contact your doctor immediately.
If you miss a dose of Clomid: Take it as soon as you remember. If it is
time for your next dose of Clomid, take the 2 doses together and go back to your regular
schedule. If you miss more than 1 dose of Clomid, contact your doctor.
Storage instructions for Clomid: Store at room temperature in a tightly
closed container, away from light, moisture, and excessive heat.
Preparations of Clomid Tablets: Clomid 50 mg.
|Special Information on Clomid
|Special information if you are pregnant or breastfeeding: If you become
pregnant, notify your doctor immediately. You should not be taking Clomid
while you are pregnant.
Most Important Fact about Clomid: Properly timed sexual intercourse is
very important to increase the chances of conception. The likelihood of conception diminishes with each succeeding course of treatment. Your doctor will determine
the need for continuing therapy after the first course. If you do not ovulateafter 3 courses or do not become pregnant after 3 ovulations, your doctor will
stop the therapy.
|Clomid side effects
|Side effects of Clomid occur infrequently and generally do not interfere
with treatment at the recommended dosage of clomiphene. They tend to occur more
frequently at higher doses and during long-term treatment.
More common side effects of Clomid: Include, Abdominal discomfort,
enlargement of the ovaries, hot flushes.
Less common side effects of Clomid: Include, Abnormal uterine bleeding,
breast tenderness, depression, dizziness, fatigue, hair loss, headache, hives,
inability to fall or stay asleep, increased urination, inflammation of the skin,
light-headedness, nausea, nervousness, ovarian cysts, visual disturbances, vomiting,
|Special warnings about Clomid
|Your doctor will evaluate you for normal liver function and normal estrogen levels
before considering you for treatment with Clomid (clomiphene). Your doctor
will also examine you for pregnancy, ovarian enlargement, or cyst formation prior
to treatment with Clomid and between each treatment cycle. He or she will
do a complete pelvic examination before each course of Clomid.
Clomid (Clomiphene) treatment increases the possibility of multiple births;
also, birth defects have been reported following treatment to induce ovulation
with clomiphene, although no direct effects of Clomid on the unborn child have
been established. Because blurring and other visual symptoms may occur occasionally
with clomiphene treatment, you should be cautious about driving a car or operating
dangerous machinery, especially under conditions of variable lighting.
If you experience visual disturbances, notify your doctor immediately. Symptoms
of visual disturbance may include blurring, spots or flashes, double vision, intolerance
to light, decreased visual sharpness, loss of peripheral vision, and distortion
of space. Your doctor may recommend a complete evaluation by an eye specialist.
Ovarian hyperstimulation syndrome (or OHSS, enlargement of the ovary) has occurred
in women receiving treatment with clomiphene. OHSS may progress rapidly and become
The early warning signs are severe pelvic pain, nausea, vomiting, and weight gain
while taking Clomid. Symptoms include abdominal pain, abdominal enlargement,
nausea, vomiting, diarrhea, weight gain, difficult or labored breathing, and less
urine production. If you experience any of these warning signs or symptoms, notify
your doctor immediately.
To lessen the risks associated with abnormal ovarian enlargement during treatment
with clomiphene, the lowest effective dose should be prescribed.
Women with the hormonal disorder, polycystic ovarian syndrome, may be unusually
sensitive to certain hormones and may respond abnormally to usual Clomid doses.
If you experience pelvic pain, notify your doctor. He may discontinue your use
of clomiphene until the ovaries return to pretreatment size. Because the safety
of long-term treatment with clomiphene has not been established, your doctor will
not prescribe more than about 6 courses of therapy. Prolonged use of Clomid
may increase the risk of a tumor in the ovaries.
[ Back ]