|Drug Class: What is Surmontil ? and why is it prescribed?
| Surmontil (Trimipramine maleate) is an antidepressant.
Surmontil can treat your depression by lifting your mood, especially if it is associated with sleep disturbances. Improvement of sleep patterns and anxiety can be the first benefits of treatment.
Surmontil may be prescribed for other conditions, such as relief from nerve pain.
|Surmontil Mechanism: How does Surmontil work?
| Surmontil belongs to a group of medicines known as tricyclic antidepressants (TCA).
When depression occurs, there may be a decreased amount of the chemicals noradrenaline and serotonin released from nerve cells in the brain. When these chemicals are released from nerve cells they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood.
Surmontil works by preventing this re-absorption of noradrenaline and serotonin back into the nerve cells. Therefore, it helps prolong the mood-lightening effect of any released noradrenaline and serotonin. This helps relieve depression.
Surmontil also blocks receptors in other areas of the body resulting in side effects such as drowsiness. Therefore, Surmontil may be particularly useful in the treatment of depression involving sleep disturbances, anxiety or agitation.
It may be seven to ten days before any benefits of treatment with Surmontil are seen.
|Surmontil Dosage: How should you take Surmontil
| Take Surmontil by mouth.
Swallow the capsules with a drink of water. You can take the capsules with or without food.
Elderly patients over 65 years old and adolescents may have a stronger reaction to Surmontil and need smaller doses.
The usual starting dose is 75 milligrams per day, divided into equal smaller doses. Your doctor may gradually increase your dose to 150 milligrams per day, divided into smaller doses. Doses over 200 milligrams a day are not recommended. Doses in long-term therapy may range from 50 to 150 milligrams daily. You can take this total daily dosage at bedtime or spread it throughout the day.
Safety and effectiveness of Surmontil in children have not been established.
Older Adults and Adolescents
Dosages usually start at 50 milligrams per day. Your doctor may increase the dose to 100 milligrams a day, if needed.
If you miss a Surmontil dose
If you miss a dose of Surmontil, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses of Surmontil.
Surmontil overdose can lead to serious consequences. Seek medical emergency immediately.
Symptoms of Surmontil overdose include
• dilated pupils,
• disturbed concentration,
• high fever,
• irregular heart rate,
• low body temperature,
• muscle rigidity,
• overactive reflexes,
• severely low blood pressure,
Surmontil Storage instructions
Keep Surmontil out of reach of children.
Store the Surmontil tablets at room temperature 15-30°C (59-86°F), away from direct heat and light. Do not freeze. Keep the prescription bottle tightly closed. Throw away any unused amount of Surmontil after the expiration date.
Preparations: Tablet- 10mg, 25mg
|Possible food and drug interactions when taking Surmontil
| If Surmontil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Surmontil with the following:
Antidepressants such as Desyrel and Wellbutrin
Antidepressants that act on serotonin, such as Prozac, Paxil, and Zoloft
Antispasmodic drugs such as Donnatal and Cogentin
Drugs for heart irregularities, such as Rythmol and Tambocor
Local anesthetics containing epinephrine
Local decongestants such as Dristan Nasal Spray
Major tranquilizers such as Thorazine and Mellaril
Quinidine (Quinidex, Quinaglute)
Stimulants such as Proventil, Sudafed, and EpiPen
Thyroid medications such as Synthroid
Extreme drowsiness and other potentially serious effects may result if you drink alcoholic beverages while you are taking Surmontil.
|Special information on Surmontil
| Most Important Fact about Surmontil
People who are taking antidepressants known as MAO inhibitors (Parnate and Nardil) should not take Surmontil. Wait 2 weeks after stopping an MAO inhibitor before you begin taking Surmontil.
Surmontil precautions if you are pregnant or breastfeeding
The safety of Surmontil during pregnancy has not been established. The manufacturer therefore advises that it should be avoided during pregnancy. Seek medical advice from your doctor.
Significant amounts of Surmontil may pass into breast milk. Breastfeeding mothers should not use Surmontil. Discuss this with your doctor.
Special warnings about Surmontil
Surmontil may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how Surmontil affects you and you are sure it wont affect your performance.
Surmontil may cause low blood sodium levels (hyponatraemia), which can result in drowsiness, confusion, muscle twitching or convulsions. Consult your doctor if you develop any of these symptoms while taking Surmontil.
People taking Surmontil for prolonged periods should have their liver function monitored.
|Surmontil side effects
| Surmontil should not be used if you suffer from severe liver disease or heart block (defect of the hearts electrical message pathways resulting in decreased function of the heart) or irregular heartbeats (arrhythmias).
Surmontil should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using Surmontil and inform your doctor or pharmacist immediately.
Possible Surmontil Side effects
More common side effects of Surmontil may include:
• dryness of mouth,
• increased appetite,
• tiredness or weakness (mild),
• unpleasant taste,
• weight gain
Less common side effects of Surmontil may include:
• blurred vision,
• confusion or delirium,
• constipation, decreased sexual ability,
• difficulty in speaking or swallowing,
• eye pain,
• fast or irregular heartbeat,
• loss of balance control,
• mask-like face,
• nervousness or restlessness,
• problems in urinating,
• shakiness or trembling,
• shuffling walk,
• slowed movements,
• stiffness of arms and legs
Rare side effects of Surmontil may include
• breast enlargement in both males and females,
• hair loss,
• inappropriate secretion of milking females,
• increased sensitivity to sunlight,
• muscle twitching,
• red or brownish spots on skin,
• buzzing, or other unexplained sounds in the ears,
• skin rash and itching,
• sore throat and fever,
• swelling of face and tongue,
• swelling of testicles,
• trouble with teeth or gums,
• yellow eyes or skin
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