|Drug Class: What is Diclofenac? an why is it prescribed?
|Diclofenac Sodium EC is a nonsteroidal anti-inflammatory drug used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (arthritis and stiffness of the spine).
|Diclofenac Sodium EC Mechanism: How does Diclofenac work?
| Diclofenac Sodium EC contains the active ingredient diclofenac sodium, which is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). All the medicines in the NSAID group reduce inflammation caused by the body\'s own immune system and are effective painkillers.
Diclofenac Sodium EC works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. The body in response to injury and certain diseases produces prostaglandins and they go on to cause the pain, swelling and inflammation of these conditions. Arthritic conditions are one example of this.
As Diclofenac Sodium EC stops the body producing these inflammatory prostaglandins, it relieves the associated pain and inflammation.
Diclofenac Sodium EC is used to relieve pain and inflammation in a wide range of musculoskeletal conditions, including arthritis, gout, sprains, fractures, dislocations, back pain, tendinitis and frozen shoulder. Diclofenac Sodium EC is also used to relieve pain and inflammation following dental, orthopaedic (bone) and other minor surgery.
|Diclofenac Sodium EC Dosage: How should you take Diclofenac
| Take Diclofenac Sodium EC tablets by mouth. Swallow the tablets whole with a full glass of water; take tablets in an upright or sitting position. Do not crush or chew tablets. Taking a sip of water first, before taking the tablets, may help you swallow them. It is better to take Diclofenac Sodium EC with food.
The usual dose of Diclofenac Sodium EC is 50 milligrams 2 or 3 times a day.
The usual dose of Diclofenac Sodium EC is 50 milligrams 2 or 3 times a day.
People with rheumatoid arthritis should not take more than 225 milligrams of Diclofenac Sodium EC a day.
The usual dose of Diclofenac Sodium EC is 25 milligrams 4 times a day.
Pain and menstrual discomfort
The usual starting dose of Diclofenac sodium EC is 50 milligrams every 8 hours as needed, although to provide better relief on the first day doctors sometimes prescribe a starting dose of 100 milligrams followed by two 50-milligram doses. After the first day, you should not take more than 150 milligrams in a day.
The safety and effectiveness of Diclofenac Sodium EC have not been established in children.
If you miss a Diclofenac Sodium EC dose
If you miss a dose of Diclofenac Sodium EC, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses of Diclofenac Sodium EC.
Diclofenac Sodium EC Overdose
Diclofenac Sodium EC may lead to serious consequences. Seek medical emergency immediately.
Symptoms of Diclofenac Sodium EC overdose may include
• acute kidney failure,
• loss of consciousness,
• lung inflammation,
Diclofenac Sodium EC Storage instructions
Keep Diclofenac Sodium EC out of the reach of children in a container that small children cannot open.
Store Diclofenac Sodium EC at room temperature below 30 degrees C (86 degrees F). Protect from moisture. Keep container tightly closed. Throw away any unused amount of Diclofenac Sodium EC after the expiration date.
Preparations: Diclofenac Sodium EC tablet - 50mg
|Possible food and drug interactions when taking Diclofenac
| Tell your doctor if you are taking any medicines, including those bought over-the-counter and herbal medicines, before you start treatment with Diclofenac Sodium EC. Similarly, check with your doctor or pharmacist before you take any new medicines while you are taking Diclofenac Sodium EC.
Diclofenac Sodium EC may increase the blood levels of the following medicines:
People taking Diclofenac Sodium EC with any of the above should be closely monitored by their doctor.
There may be an increased risk of bleeding if Diclofenac Sodium EC is taken with blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. People taking Diclofenac Sodium EC with an anticoagulant should be closely monitored by their doctor.
There may be an increased risk of side effects such as stomach irritation if Diclofenac Sodium EC is taken with corticosteroids such as prednisolone.
Diclofenac Sodium EC should not be taken with any other NSAID, eg ibuprofen, as this increases the risk of side effects, particularly on the gut.
Ciclosporin may increase the blood level of Diclofenac Sodium EC, and your doctor may prescribe a lower than normal dose of diclofenac if you are taking ciclosporin.
There may be an increased risk of side effects on the kidneys if Diclofenac Sodium EC is taken with any of the following medicines:
- ACE inhibitors, eg enalapril
- diuretics, eg frusemide (furosemide).
Diclofenac Sodium EC may reduce the blood pressure lowering effects of diuretics such as frusemide (furosemide).
There may potentially be an increased risk of seizures if Diclofenac Sodium EC is taken together with quinolone antibiotics such as ciprofloxacin.
|Special information on Diclofenac
| Most Important Fact about Diclofenac Sodium EC
You should have frequent checkups with your doctor if you take Diclofenac Sodium EC regularly. Ulcers or internal bleeding can occur without warning.
Diclofenac Sodium EC precautions if you are pregnant or breastfeeding
Do not take Diclofenac Sodium EC late in your pregnancy; it could harm the baby.
Check with your doctor before taking Diclofenac Sodium EC early in pregnancy; it should be used only if necessary.
Diclofenac Sodium EC does appear in breast milk and could affect a nursing infant. If Diclofenac Sodium EC is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with it is finished.
Special warnings about Diclofenac Sodium EC
Diclofenac Sodium EC may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how Diclofenac Sodium EC affects you and you are sure it won\'t affect your performance.
People with impaired kidney, liver or heart function who are taking Diclofenac Sodium EC should have their kidney function monitored.
During long-term treatment, routine blood tests are recommended to monitor kidney function, liver function and levels of blood components, particularly in the elderly.
Diclofenac Sodium EC may mask the signs and symptoms of infection. This may make you think mistakenly that an infection is getting better when it isn\'t, or that an infection is less serious than it is. For this reason you should tell your doctor if you get an infection while you are taking Diclofenac Sodium EC.
It is important that people with a history of disorders affecting the stomach or intestines are closely monitored by a doctor while taking Diclofenac Sodium EC, particularly if elderly. Consult your doctor immediately if you experience side effects such as stomach pain, indigestion, heartburn or signs of bleeding in the stomach or intestines, eg blood in the stools, while taking Diclofenac Sodium EC.
Close medical supervision is important in people suffering from severe impairment of liver function.
|Diclofenac side effects
| Why Diclofenac Sodium EC should not be prescribed?
Diclofenac Sodium EC should not be used by people in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema)
Diclofenac Sodium EC should not be used if you have a history of bleeding from the stomach or intestines.
Diclofenac Sodium EC should not be used if suspect or have a history of Peptic ulcer.
Diclofenac Sodium EC should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using Diclofenac Sodium EC and inform your doctor or pharmacist immediately.
Possible Diclofenac Sodium EC Side effects
More common side effects of Diclofenac Sodium EC may include:
• abdominal pain or cramps,
Less common side effects of Diclofenac Sodium EC may include:
• abdominal bleeding,
• abdominal swelling,
• fluid retention,
• peptic ulcers,
• ringing in the ears
Rare side effects of Diclofenac Sodium EC may include:
• anaphylaxis (severe allergic reaction),
• appetite change,
• black stools,
• blood disorders,
• bloody diarrhea,
• blurred vision,
• changes in taste,
• congestive heart failure,
• decrease in white blood cells,
• decreased urine production,
• depression, double vision,
• dry mouth and mucous membranes,
• hair loss,
• hearing loss,
• high blood pressure,
• inability to sleep,
• inflammation of the colon,
• inflammation of mouth,
• inflammation of the pancreas,
• kidney failure,
• liver disease,
• low blood pressure,
• red or purple skin discoloration and itching,
• sensitivity to light,
• skin eruptions and inflammation,
• scaling or peeling,
• sores in the gullet,
• Stevens-Johnson syndrome (a severe form of skin eruption),
• swelling of eyelids, lips, and tongue,
• swelling of the throat due to fluid retention,
• vague feeling of illness,
• vision changes,
• yellow eyes and skin
[ Back ]